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1,4-Butanediol Info: Name: 1,4-Butanediol Synonyms:1,4-Butylene Glycol;1,4-Butanediol;1,4-Dihydroxybutane;Butanediol, 1,4-;Tetramethylene Glycol;Versalink Curative 1,4 Bdo CAS:110-63-4 MF:C4H10O2 MW:90.12 EINECS:203-786-5 Chemical Properties: mp 20 °C bp 230 °C(lit.) density 1.017 g/mL at 25 °C(lit.) vapor density 3.1 (vs air) refractive index n20/D 1.445(lit.) Fp 135 °C storage temp. 2-8°C Water Solubility Miscible Sensitive Hygroscopic BRN 1633445 Stability: Stable. Combustible. Incompatible with strong oxidizing agents, mineral acids, acid chlorides, acid anhydrides. Usage:1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. 1,4-Butanediol Descrption 1,4-Butanediol is heat and light sensitive. 1,4-Butanediol reacts with acid chlorides, acid anhydrides and chloroformates. 1,4-Butanediol also reacts with oxidizing agents and reducing agents. 1,4-Butanediol is incompatible with isocyanates and acids. 1,4-Butanediol is also incompatible with peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide and chlorine.
1,4-Butanediol Application
1,4-Butanediol is used industrially as a solvent and in the manufacture of some types of plastics, elastic fibers and polyurethanes. In organic chemistry. In the presence of phosphoric acid and high temperature, it dehydrates to the important solvent tetrahydrofuran. At about 200 °C in the presence of soluble ruthenium catalysts, the diol undergoes dehydrogenation to form butyrolactone.
In humans, it acts as a depressant and a prodrug for Gam H-B where 1ml is equivalent to 1g of Gam HB. It is used as a recreational intoxicant with effects similar to alcohol. 1,4-Butanediol, as well as Gam B-L, will dissolve most types of plastic over time.For this reason, it is recommended to only transport and store the drug using a glass container, standard gelatin capsules (not vegetarian), or high-density polyethylene plastic (also known as #2 recycled plastic). To check the type of plastic used on a bottle, one can look at the bottom for a number in the triangle shaped recycling label.
