Acitretin Pharmaceutical Raw Yellow Powder Acitretin cindy1114@yccreate.com
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Acitretin detail
Product: Acitretin Category: A synthetic retinoid CAS:55079-83-9 MF: C21H26O3 MW:326.43 EINECS:259-474-4 Character: Yellow or light orange crystalline powder MP: 228-230°C Assay: 99%min storage temp: 2-8°C Package: 100G/500G/1KG/bag Description: A synthetic retinoid which is the major metabolite of etretinate.
Acitretin Descrption
1. Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin.
Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant.
2. Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer. If a patient has received the medication, he/she is advised against giving blood for at least 3 years due to the risk of birth defects.
Acitretin Application
For the treatment of psoriasis (severe refractory cases, including erythrodermic andgeneralized pustular), severe refractory oral lichen planus, keratosis refractory severeintractable disorders (such as ichthyosis-like skin disease, congenital ichthyosis-likeerythroderma, lamellar ichthyosis and other ichthyosis), follicular keratosis, palmoplantarkeratosis, pityriasis rubra pilaris, palmoplantar pus fibromatosis.
Acitretinis widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..
For skin keratinocytes-resistant drugs and cell-induced differentation drug.
