Acute Pain Control Drug Ropivacaine HCl for Local Anesthetic
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Name: Ropivacaine hydrochloride CAS No.: 132112-35-7 Appearance:White to white crystalls or crystal powder Formula: C17H29ClN2O2 Molecular Weight: 328.88 Melting Point: 267-269 °C Boiling Point: 410.2 °C at 760 mmHg Flash Point: 201.9 °C Appearance: white solid Surgical anesthesia, epidural anesthesia
Description:
Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.
Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.
Ropivacaine may also be used for purposes not listed in this medication guide.
Levobupivacaine hydrochloride is a sodium channel blocker used as a long-acting local anaesthetic for epidural anesthesia. Levobupivacaine is the isomer of bupivacaine, with efficacy similar to that of bupivacaine with a reduced risk of cardiotoxicity.
Levobupivacaine has been studied in surgical anaesthesia and for pain management. It can be used for local infiltration, epidural, intrathecal and peripheral nerve blocks. For epidural analgesia it can be given with clonidine. Double-blind comparisons of levobupivacaine and bupivacaine show that their anaesthetic effects are similar.
Clinical Use
Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecalanaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudalepidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children. Ropivacaine is often coadministered with fentanyl for epidural analgesia, for example in pregnant women during labour.
Dosage Recommended
For treatment of postoperative pain, the following technique can be recommended: If regional anesthesia was not used intraoperatively, then an initial epidural block with 5 to 7 mL Naropin (ropivacaine hcl) is induced via an epidural catheter. Analgesia is maintained with an infusion of Naropin (ropivacaine hcl) , 2 mg/mL (0.2%). Clinical studies have demonstrated that infusion rates of 6 to 14 mL (12 to 28 mg) per hour provide adequate analgesia with nonprogressive motor block. With this technique a significant reduction in the need for opioids was demonstrated. Clinical experience supports the use of Naropin (ropivacaine hcl) epidural infusions for up to 72 hours.
